Prostanoid receptors involved in the relaxation of human pulmonary vessels

摘要

1. To characterize the prostanoid receptors on human pulmonary smooth muscle involved in vasodilatations, isolated arteries and veins were contracted with norepinephrine (10 μM) and vessels were subsequently challenged with different prostanoid-receptor agonists in the absence or presence of selective antagonists. 2. Prostaglandin D_2 (PGD_2) and the selective DP-receptor agonist, BW245C, induced relaxations in the contracted human pulmonary venous preparations.