Bradykinin B_1 and B_ receptors, tumour necrosis factor α and inflammatory hyperalgesia

摘要

1. The effects of BK agonists and antagonists, and other hyperalgesic/antihyperalgesic drugs were measured (3 h after injection of hyperalgesic drugs) in a model of mechanical hyperalgesia (the end- point of which was indicated by a brief apnoea, the retraction of the head an forepaws, and muscular tremor). 2 DALBK inhibited responses to carrageenin, bradykinin, DABK, and kallidin. 3. Responses to kallidin and DABK were inhibited by indomethacin or atenolol and abolished by the combination of indomethacin + atenolol.