AngiotensinⅡis involved in nitric oxide synthase and cyclo-oxygenase inhibition-induced leukocyte-endothelial cell interactions in vivo

摘要

Chronic inhibition of nitric oxide synthase(NOS)provokes a hypertensive state which has been shown to be angiotensinⅡ(Ang-Ⅱ)dependent. In addition to raising blood pressure, NOS inhibition also causes leukocyte adhesion. The present study was designed to define the role of Ang- Ⅱin hypertension and in the leukocyte-endothelial cell interactions induced by acute NOS or cyclo- oxygenase(COX)inhibition using inntravital microscopy within the rat mesenteric microcirculation. While pretreatment with an Ang-ⅡAT_1 receptor antagonist(losartan)reversed the prompt Increase in mean arterial blood pressure(MABP)caused by indomethacin, it had no effect on the Increase evoked by systemic L-NAME administration.