The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma

J.E. Kim; H.J. Kim; J.M. Choi; K.H. Lee; T.Y. Kim; B.K. Cho; J.Y. Jung; K.Y. Chung; D. Cho; H.J. Park

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The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma

机译：抗菌肽人阳离子抗菌蛋白-18 / cathelicidin LL-37作为恶性黑色素瘤的假定生长因子

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SummaryBackground Recent evidence suggests cathelicidin LL-37 to be a growth factor for various human cancers such as lung cancer, ovarian cancer and breast cancer. However, the effect of LL-37 against malignant skin cancer has not been reported.

机译：概述背景最近的证据表明，cathelicidin LL-37是多种人类癌症（例如肺癌，卵巢癌和乳腺癌）的生长因子。但是，尚未报道LL-37对恶性皮肤癌的作用。

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来源
《British Journal of Dermatology》 |2010年第5期|p.959-967|共9页
作者
J.E. Kim; H.J. Kim; J.M. Choi; K.H. Lee; T.Y. Kim; B.K. Cho; J.Y. Jung; K.Y. Chung; D. Cho; H.J. Park;
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作者单位

Department of Dermatology, College of Medicine, The Catholic University of Korea, 62 Youido-dong, Youngdeunpo-gu, Seoul 15-713, Korea;

Department of Dermatology, College of Medicine, The Catholic University of Korea, 62 Youido-dong, Youngdeunpo-gu, Seoul 15-713, Korea;

HB Dermatology Clinic, Seoul, Korea;

Department of Dermatology, College of Medicine, The Catholic University of Korea, 62 Youido-dong, Youngdeunpo-gu, Seoul 15-713, Korea;

Department of Dermatology, College of Medicine, The Catholic University of Korea, 62 Youido-dong, Youngdeunpo-gu, Seoul 15-713, Korea;

Department of Dermatology, College of Medicine, The Catholic University of Korea, 62 Youido-dong, Youngdeunpo-gu, Seoul 15-713, Korea;

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea;

Department of Dermatology and Cutaneous Biology Research Institute, Yo;

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正文语种 eng
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antimicrobial peptide; LL-37; malignant skin cancer; melanoma; skin tumours; tumour progression;

机译：抗菌肽;LL-37;恶性皮肤癌;黑色素瘤;皮肤肿瘤;肿瘤进展;

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专利

1. The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma. [J] . Kim JE, Kim HJ, Choi JM, British Journal of Dermatology . 2010,第5期

机译：抗菌肽人阳离子抗菌蛋白-18 / cathelicidin LL-37作为恶性黑色素瘤的假定生长因子。
2. Cell Differentiation Is a Key Determinant of Cathelicidin LL-37/Human Cationic Antimicrobial Protein 18 Expression by Human Colon Epithelium [J] . Koji Hase, Lars Eckmann, John D. Leopard, Infection and immunity . 2002,第2期

机译：细胞分化是人类结肠上皮细胞Cathelicidin LL-37 /人类阳离子抗菌蛋白18表达的关键决定因素
3. An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7 [J] . Isao Nagaoka, Hiroshi Tamura, Michimasa Hirata The journal of immunology . 2006,第5期

机译：抗菌肽Cathelicidin肽人CAP18 / LL-37通过甲酰肽受体样1和P2X7的激活抑制中性粒细胞凋亡。
4. Mode of Action and Conformation of Cationic Antimicrobial Peptides NP1P-NP3P Derived from Natural Non-Antimicrobial Sequences by Acid-Amide Substitution [C] . Satoshi Ueno, Masaomi Minaba, Yasushi Tamada Japanese peptide symposium . 2010

机译：阳离子抗微生物肽NP1P-NP3P酸酰胺取代衍生自天然非抗微生物序列的作用和构象
5. Molecular Mechanisms Regulating the Activation of Eosinophils Induced by S. aureus-associated NOD2/TLR2 Ligands, Alarmin HMGB1 and Antimicrobial Peptide LL-37 in Allergic Inflammation [D] . Jiao, Delong. 2016

机译：金黄色葡萄球菌相关NOD2 / TLR2配体，警报蛋白HMGB1和抗菌肽LL-37诱导变应性炎症诱导嗜酸性粒细胞激活的分子机制。
6. Anti-adenoviral Effects of Human Cationic Antimicrobial Protein-18/LL-37 an Antimicrobial Peptide by Quantitative Polymerase Chain Reaction [O] . Eiichi Uchio, Hirotoshi Inoue, Kazuaki Kadonosono 2013

机译：定量聚合酶链反应对人阳离子抗菌蛋白-18 / LL-37（一种抗菌肽）的抗腺病毒作用
7. Anti-adenoviral Effects of Human Cationic Antimicrobial Protein-18/LL-37, an Antimicrobial Peptide, by Quantitative Polymerase Chain Reaction [O] . Eiichi Uchio, Hirotoshi Inoue, Kazuaki Kadonosono 2013

机译：通过定量聚合酶链反应的人阳离子抗菌蛋白-18 / L17，一种抗微生物肽的抗腺病毒作用

The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma

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