Androgen receptor and 5-reductase immunohistochemical profiles in extramammary Paget disease

摘要

SummaryBackground Extramammary Paget disease is an uncommon skin tumour occurring mostly in the genitoperineal region. Previous reports have shown frequent expression of androgen receptor, suggesting a tumour-proliferative effect of androgens on Paget cells. Androgen-converting enzymes such as 5-reductase, which locally produces a bioactive androgen, have recently gained attention in studies of the intratumoral actions of androgens.