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Causality and pathway search in microarray time series experiment

机译:微阵列时间序列实验中的因果关系和途径搜索

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Motivation: Interaction among time series can be explored in many ways. All the approach has the usual problem of low power and high dimensional model. Here we attempted to build a causality network among a set of time series. The causality has been established by Granger causality, and then constructing the pathway has been implemented by finding the Minimal Spanning Tree within each connected component of the inferred network. False discovery rate measurement has been used to identify the most significant causalities.Results: Simulation shows good convergence and accuracy of the algorithm. Robustness of the procedure has been demonstrated by applying the algorithm in a non-stationary time series setup. Application of the algorithm in a real dataset identified many causalities, with some overlap with previously known ones. Assembled network of the genes reveals features of the network that are common wisdom about naturally occurring networks.
机译:动机:时间序列之间的相互作用可以通过多种方式进行探索。所有方法都存在通常的低功耗和高维模型问题。在这里,我们试图在一组时间序列之间建立因果关系网络。由Granger因果关系建立因果关系,然后通过在推断网络的每个连接组件中找到最小生成树来构造路径。错误发现率测量已被用于识别最重要的因果关系。结果:仿真表明该算法具有良好的收敛性和准确性。通过在非平稳时间序列设置中应用该算法,证明了该过程的鲁棒性。该算法在实际数据集中的应用确定了许多因果关系,并且与先前已知的因果关系有所重叠。基因的组装网络揭示了网络的特征,这是有关自然发生网络的常识。

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