Coordination of bismuth and lead in porphyrins: Towards an in-situ generator for α-radiotherapy?

摘要

In order to investigate the possible coordination of both bismuth(III) and lead(II) by porphyrins for an application in alpha-radioimmunotherapy, several series of functionalized bismuth porphyrins have been synthesized and their stabilities in acidic medium were compared.rnWhere unfunctionalized porphyrins are not suitable for such a purpose, strapped hanging carboxylate porphyrins are stable and allow a rapid coordination of both bismuth and lead. This property could lead to the preparation of an in-situ generator of alpha particles by a pre-complexation of ~(212)lead, the radioactive parent of ~(212)bismuth, in the ligand.