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首页> 外文期刊>Australasian physical & engineering sciences in medicine >A fast numerical method for calculating the 3D proton dose profile in a single-ring wobbling spreading system
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A fast numerical method for calculating the 3D proton dose profile in a single-ring wobbling spreading system

机译:在单环摆动扩展系统中计算3D质子剂量分布的快速数值方法

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摘要

Based on the determination of protons fluence at the phantom's surface, a 3D dose distribution is calculated inside a water phantom using a fast method. The dose contribution of secondary particles, originating from inelastic nuclear interactions, is also taken into account. This is achieved by assuming that 60% of the energy transferred to secondary particles is locally absorbed. Secondary radiation delivers approximately 16.8% of the total dose in the plateau region of the Bragg curve for monoenergetic protons of energy 190 MeV. The physical dose beyond the Bragg peak is obtained for a proton beam of 190 MeV using a Geant4 simulation. It is found that the dose beyond the Bragg peak is <0.02% of the maximum dose and is mainly delivered by protons produced via reactions of the secondary neutrons. The relative dose profile is also calculated by simulation of the proposed beam line in Geant4 code. The dose profile produced by our method agrees, within 2%, with the results predicted by the Fermi Eyges distribution function and the results of the Geant4 simulation. It is expected that the fast numerical approach proposed herein may be utilised in 3D deterministic treatment planning programs, to model proton propagation in order to analyse the effect of modifying the beam line.
机译:基于对幻影表面质子注量的确定,使用快速方法计算了水幻影内部的3D剂量分布。还考虑了源自非弹性核相互作用的次级粒子的剂量贡献。这是通过假设转移到次级粒子的60%的能量被局部吸收来实现的。对于能量为190 MeV的单能质子,二次辐射在布拉格曲线的平稳区域传递的总剂量约为总剂量的16.8%。使用Geant4模拟,对于190 MeV的质子束,获得了超过布拉格峰的物理剂量。发现超出布拉格峰的剂量小于最大剂量的0.02%,并且主要由通过次级中子反应产生的质子传递。相对剂量分布图也可以通过用Geant4代码对拟议的光束线进行仿真来计算。我们的方法产生的剂量分布与费米·艾格斯分布函数预测的结果和Geant4模拟的结果相吻合在2%之内。预期本文提出的快速数值方法可以在3D确定性治疗计划程序中使用,以对质子传播进行建模,以分析修改束线的效果。

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