A simple solid mechanical model has been developed to extract the mechanical properties of a single cell in a tapered micropipette. This analytical model is derived using the definition of elastic modulus and force equilibrium. Using the authors' model, an elastic modulus of 21.80±4.91 Pa, a Poisson ratio of 0.46±0.03, and a friction coefficient of 0.0274±0.0077 are extracted for a neutrophil cell. The model is verified by finite element software and shows good agreement with experiments. The biophysical basis of the model and application in microfluidic channels for cancer cell research are discussed, while a comparison is made with other models.
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