A randomized phase II trial evaluating safety and efficacy of an experimental chemotherapy regimen (irinotecan + oxaliplatin, IRINOX) and two standard arms (LV5–FU2 + irinotecan or LV5–FU2 + oxaliplatin) in first-line metastatic colorectal cancer: a study of the Digestive Group of the Fédération Nationale des Centres de Lutte Contre le Cancer

Y. Bécouarn1 P. Senesse2 S. Thézenas2 E. Boucher3 A. Adenis4 L. Cany5 J. H. Jacob6 F. Cvitkovic7 C. Montoto-Grillot8 and M. Ychou2

首页> 外文期刊>Annals of Oncology >A randomized phase II trial evaluating safety and efficacy of an experimental chemotherapy regimen (irinotecan + oxaliplatin, IRINOX) and two standard arms (LV5–FU2 + irinotecan or LV5–FU2 + oxaliplatin) in first-line metastatic colorectal cancer: a study of the Digestive Group of the Fédération Nationale des Centres de Lutte Contre le Cancer

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A randomized phase II trial evaluating safety and efficacy of an experimental chemotherapy regimen (irinotecan + oxaliplatin, IRINOX) and two standard arms (LV5–FU2 + irinotecan or LV5–FU2 + oxaliplatin) in first-line metastatic colorectal cancer: a study of the Digestive Group of the Fédération Nationale des Centres de Lutte Contre le Cancer

机译：一项II期随机试验，评估一线转移性结直肠癌的实验性化疗方案（伊立替康+奥沙利铂，IRINOX）和两个标准组（LV5-FU2 +伊立替康或LV5-FU2 +奥沙利铂）的安全性和有效性：中央国家癌症中心消化小组

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Background: To assess activity and safety of an experimental combination of irinotecan and oxaliplatin (IRINOX) as first-line treatment in advanced colorectal cancer.

机译：背景：评估伊立替康和奥沙利铂（IRINOX）作为晚期大肠癌一线治疗的实验组合的活性和安全性。

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《Annals of Oncology》 |2007年第12期|2000-2005|共6页
作者
Y. Bécouarn1 P. Senesse2 S. Thézenas2 E. Boucher3 A. Adenis4 L. Cany5 J. H. Jacob6 F. Cvitkovic7 C. Montoto-Grillot8 and M. Ychou2;
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Department of Digestive Oncology Institut Bergonié Regional Cancer Center Bordeaux;

Centre Régional de Lutte contre le Cancer Val d′Aurelle-Paul Lamarque Montpellier;

Centre Eugène Marquis Rennes;

Centre Oscar Lambret Lille;

Clinique Francheville Périgueux;

Centre François Baclesse Caen;

Centre René Huguenin Saint-Cloud;

Fédération Nationale des Centres de Lutte Contre le Cancer Paris France;

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1. A randomized phase II trial evaluating safety and efficacy of an experimental chemotherapy regimen (irinotecan + oxaliplatin, IRINOX) and two standard arms (LV5 FU2 + irinotecan or LV5 FU2 + oxaliplatin) in first-line metastatic colorectal cancer: a [J] . Becouarn Y, Senesse P, Thezenas S, Annals of oncology: official journal of the European Society for Medical Oncology . 2007,第12期

机译：一项II期随机试验，评估一线转移性结直肠癌的化学治疗方案（伊立替康+奥沙利铂，IRINOX）和两个标准组（LV5 FU2 +伊立替康或LV5 FU2 +奥沙利铂）的安全性和有效性：
2. Prospective, randomized, multicenter, phase III study of fluorouracil, leucovorin, and irinotecan versus epirubicin, cisplatin, and capecitabine in advanced gastric adenocarcinoma: A French intergroup (Fédération Francophone de Cancérologie Digestive, Fédération Nationale des Centres de Lutte Contre le Cancer, and Groupe Coopérateur Multidisciplinaire en Oncologie) study [J] . GuimbaudR., LouvetC., RiesP., Journal of Clinical Oncology . 2014,第31期

机译：氟尿嘧啶，亚叶酸钙和伊立替康与表柔比星，顺铂和卡培他滨在晚期胃腺癌中的前瞻性，随机，多中心，III期研究：法国的一个研究小组（法国消化道法语国家联盟，法国国家癌症研究中心和法国吕特·孔特尔癌症研究中心，肿瘤学多学科合作者）研究
3. Prospective, randomized, multicenter, phase III study of fluorouracil, leucovorin, and irinotecan versus epirubicin, cisplatin, and capecitabine in advanced gastric adenocarcinoma: A French intergroup (Fédération Francophone de Cancérologie Digestive, Fédération Nationale des Centres de Lutte Contre le Cancer, and Groupe Coopérateur Multidisciplinaire en Oncologie) study [J] . GuimbaudR., LouvetC., RiesP., Journal of Clinical Oncology . 2014,第31期

机译：氟尿嘧啶，亚叶酸钙和伊立替康与表柔比星，顺铂和卡培他滨在晚期胃腺癌中的前瞻性，随机，多中心，III期研究：法国的一个研究小组（法国消化道法语国家联盟，法国国家癌症研究中心和法国吕特·孔特尔癌症研究中心，肿瘤学多学科合作者）研究
4. Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1 irinotecan and bevacizumab as first-line therapy for metastatic colorectal cancer [O] . Yoshito Komatsu, Chikashi Ishioka, Ken Shimada, 2015

机译：TRICOLORE试验的研究方案：基于奥沙利铂的化疗与联合化疗联合S-1伊立替康和贝伐单抗作为转移性结直肠癌一线治疗的随机III期研究
5. Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1, irinotecan, and bevacizumab as first-line therapy for metastatic colorectal cancer [O] . 2015

机译：TRICOLORE试验的研究方案：以奥沙利铂为基础的化疗与联合用S-1，伊立替康和贝伐单抗联合化疗作为转移性结直肠癌一线治疗的III期随机研究

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