Second-line chemotherapy with pemetrexed after gemcitabine failure in patients with advanced pancreatic cancer: a multicenter phase II trial

S Boeck1 K Weigang-K?hler2 M Fuchs3 E Kettner4 D Quietzsch5 J Trojan6 O St?tzer7 S Zeuzem8 F Lordick9 C-H K?hne10 H Kr?ning11 T Steinmetz12 H Depenbrock13 and V Heinemann1

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Second-line chemotherapy with pemetrexed after gemcitabine failure in patients with advanced pancreatic cancer: a multicenter phase II trial

机译：吉西他滨治疗失败后培美曲塞二线化疗在晚期胰腺癌患者中的作用：一项多中心II期试验

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Background: A standard second-line chemotherapy regimen has yet to be defined for patients with gemcitabine (Gem)-refractory advanced pancreatic cancer (PC).

机译：背景：对于吉西他滨（Gem）难治性晚期胰腺癌（PC）的患者，尚未确定标准的二线化疗方案。

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《Annals of Oncology》 |2007年第4期|745-751|共7页
作者
S Boeck1 K Weigang-K?hler2 M Fuchs3 E Kettner4 D Quietzsch5 J Trojan6 O St?tzer7 S Zeuzem8 F Lordick9 C-H K?hne10 H Kr?ning11 T Steinmetz12 H Depenbrock13 and V Heinemann1;
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Department of Internal Medicine III University Hospital Grosshadern Ludwigs-Maximilians University Munich;

Medical Department V Hospital Nürnberg-Nord Nürnberg;

Medical Department II Hospital Bogenhausen Munich;

Department of Hematology and Oncology City Hospital Magdeburg Magdeburg;

Department of Internal Medicine II Hospital Chemnitz Chemnitz;

Medical Department I Johann Wolfgang Goethe University Hospital Frankfurt am Main;

Practice for Oncology Munich;

Department of Internal Medicine II University Hospital Saarland Homburg/Saar;

Medical Department III Klinikum rechts der Isar Technical University Munich;

Medical Department I University Hospital Dresden;

Practice for Oncology Magdeburg;

Practice for Oncology Cologne;

Medical Department Lilly Deutschland GmbH Bad Homburg Germany;

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1. Second-line chemotherapy with pemetrexed after gemcitabine failure in patients with advanced pancreatic cancer: a multicenter phase II trial. [J] . Boeck S, Weigang-Kohler K, Fuchs M, Annals of oncology: official journal of the European Society for Medical Oncology . 2007,第4期

机译：吉西他滨治疗失败后的培美曲塞二线化疗对晚期胰腺癌的患者：一项多中心II期试验。
2. An international, multicenter, randomized phase III study of first-line erlotinib followed by second-line cisplatin/gemcitabine versus first-line cisplatin/gemcitabine followed by second-line erlotinib in advanced non-small-cell lung cancer: treatment rationale and protocol dynamics of the TORCH trial. [J] . Gridelli C, Butts C, Ciardiello F, Clinical lung cancer . 2008,第4期

机译：国际，多中心，随机，III期研究对晚期非小细胞肺癌一线埃罗替尼，二线顺铂/吉西他滨与一线顺铂/吉西他滨，二线埃洛替尼进行二线研究：治疗原理和方案动态TORCH审判。
3. Elderly patients benefit from second-line cytotoxic chemotherapy: a subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced non-small-cell lung cancer. [J] . Weiss GJ, Langer C, Rosell R, Journal of Clinical Oncology . 2006,第27期

机译：老年患者受益于二线细胞毒性化疗：对先前接受治疗的晚期非小细胞肺癌患者进行培美曲塞与多西他赛比较的一项随机III期临床试验的亚组分析。
4. Pemetrexed versus docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer [C] . Hua Xin, Zhenguo Han, Haibo Huang 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：培美曲塞与多西他赛单药化疗在未接受化疗的老年晚期非小细胞肺癌患者中的作用
5. Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy [D] . 鈴木, 裕子 2019

机译：吉西他滨联合顺铂一线化疗对晚期胆道癌患者治疗效果的预测因素
6. A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer [O] . G P Stathopoulos, K Syrigos, G Aravantinos, 2006

机译：一项多中心III期试验比较了伊立替康-吉西他滨（IG）与吉西他滨（G）单药治疗作为局部晚期或转移性胰腺癌患者的一线治疗
7. Single-Agent Pemetrexed or Sequential Pemetrexed/Gemcitabine as Front-Line Treatment of Advanced Non-small Cell Lung Cancer in Elderly Patients or Patients Ineligible for Platinum-Based Chemotherapy: A Multicenter, Randomized, Phase II Trial [O] . Gridelli Cesare, Kaukel Eckhard, Gregorc Vanessa, 2007

机译：单药培美曲塞或序贯培美曲塞/吉西他滨作为老年患者或不适合铂类化疗的晚期非小细胞肺癌的一线治疗：多中心，随机，II期试验

Second-line chemotherapy with pemetrexed after gemcitabine failure in patients with advanced pancreatic cancer: a multicenter phase II trial

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