Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour

B. Rikhof1 J. van Doorn2 A. J. H. Suurmeijer3 M. W. Rautenberg4 P. J. T. A. Groenen5 M. A. J. Verdijk5 P. L. Jager6 S. de Jong1 J. A. Gietema1 and W. T. A. van der Graaf7*

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Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour

机译：胰岛素样生长因子和胰岛素样生长因子结合蛋白与胃肠道间质瘤患者疾病状况和低血糖发生率的关系

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Objective: Patients with a gastrointestinal stromal tumour (GIST) suffering from non-islet cell tumour-induced hypoglycaemia (NICTH), being associated with increased plasma levels of pro-insulin-like growth factor (IGF)-IIE[68-88], have been reported occasionally. We studied the clinical relevance of pro-IGF-IIE[68-88] and other IGF-related proteins in GIST patients.

机译：目的：患有非胰岛细胞瘤引起的低血糖症（NICTH）的胃肠道间质瘤（GIST）患者，其血浆胰岛素样生长因子（IGF）-IIE水平升高[68-88]，偶尔有报道。我们研究了GIST患者中pro-IGF-IIE [68-88]和其他IGF相关蛋白的临床相关性。

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《Annals of Oncology》 |2009年第9期|p.1582-1588|共7页
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B. Rikhof1 J. van Doorn2 A. J. H. Suurmeijer3 M. W. Rautenberg4 P. J. T. A. Groenen5 M. A. J. Verdijk5 P. L. Jager6 S. de Jong1 J. A. Gietema1 and W. T. A. van der Graaf7*;
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1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen 2Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht 3Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen 4Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht 5Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands 6Department of Nuclear Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada 7Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands;

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Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour

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