Improved accuracy of brain MRI/SPECT registration using a two-cluster SPECT normalization algorithm and a combinative similarity measure: application to the evaluation of Parkinson's disease

摘要

Single-photon emission computed tomography (SPECT) of dopamine transporters with technetium-99-labeled tropane derivative 99mTc-TRODAT-1 has recently been suggested to offer valuable information in assessing the functionality of dopaminergic systems. To facilitate the non-invasive examination of the dopamine concentration in vivo, registering magnetic resonance imaging (MRI) and SPECT image is important. This article proposes a new similarity measure for MRI/SPECT registration.