Electrochemical Modulation for Signal Discrimination in Surface Enhanced Raman Scattering (SERS)

摘要

Electrochemical modulation to induce controlled fluctuationsnin SERS signals is introduced as a method tondiscriminate and isolate different contributions to thenspectra. The modulationswhich can be changed in potentialnrange, amplitude, and frequencysacts as a controllablen“switch” to turn on, off, or change specific Ramannsignals which can then be correlated within the spectranby different fluctuation analysis techniques. Principalncomponent analysis (PCA), either by itself or assisted bynfast fourier transform (FFT) prefiltering, are shown tonprovide viable tools to isolate the different componentsnof the spectra. Electrochemical modulation provides,ntherefore, a technique to study complex cases of coadsorption,nand resolve problems of spectral congestion innSERS signals.