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Cannabinoids and metabolites in expectorated oral fluid after 8 days of controlled around-the-clock oral THC administration

机译:控制全天口服THC 8天后排痰液中的大麻素和代谢物

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Oral fluid (OF) is an increasingly accepted matrix for drug testing programs, but questions remain about its usefulness for monitoring cannabinoids. Expectorated OF specimens (n = 360) were obtained from 10 adult daily cannabis smokers before, during, and after 37 20-mg oral Δ9-tetrahydrocannabinol (THC) doses over 9 days to characterize cannabinoid disposition in this matrix. Specimens were extracted and analyzed by gas chromatography–mass spectrometry with electron-impact ionization for THC, 11-hydroxy-THC, cannabidiol, and cannabinol, and negative chemical ionization for 11-nor-9-carboxy-THC (THCCOOH). Linear ranges for THC, 11-hydroxy-THC, and cannabidiol were 0.25–50 ng/mL; cannabinol 1–50 ng/mL; and THCCOOH 5–500 pg/mL. THCCOOH was the most prevalent analyte in 344 specimens (96.9%), with concentrations up to 1,390.3 pg/mL. 11-hydroxy-THC, cannabidiol, and cannabinol were detected in 1, 1, and 3 specimens, respectively. THC was detected in only 13.8% of specimens. The highest THC concentrations were obtained at admission (median 1.4 ng/mL, range 0.3–113.6) from previously self-administered smoked cannabis. A total of 2.5 and 3.7% of specimens were THC-positive at the recommended Substance Abuse and Mental Health Services Administration (2 ng/mL) and Driving Under the Influence of Drugs, Alcohol and Medicines (DRUID) (1 ng/mL) confirmation cutoffs, respectively. THC is currently the only analyte for monitoring cannabis exposure in OF; however, these data indicate chronic therapeutic oral THC administration and illicit oral THC use are unlikely to be identified with current guidelines. Measurement of THCCOOH may improve the detection and interpretation of OF cannabinoid tests and minimize the possibility of OF contamination from passive inhalation of cannabis smoke.
机译:口服液(OF)是药物测试计划中越来越被接受的基质,但是有关其在监测大麻素中的用途的疑问仍然存在。从10名成年的日常大麻吸烟者中抽取了预期的OF标本(n = 360),之前,之中和之后,在9天中进行了37次20毫克口服Δ 9 -四氢大麻酚(THC)剂量的研究,以表征大麻素在大麻中的分布。这个矩阵。通过气相色谱-质谱法对样品进行提取和分析,其中电子轰击电离处理THC,11-羟基-THC,大麻二酚和大麻酚,负化学电离处理11-nor-9-羧基-THC(THCCOOH)。 THC,11-羟基-THC和大麻二酚的线性范围为0.25–50 ng / mL;大麻酚1–50 ng / mL;和THCCOOH 5–500 pg / mL。在344个样本中,THCCOOH是最普遍的分析物(96.9%),浓度高达1,390.3 pg / mL。在1个,1个和3个样本中分别检测到11-羟基四氢大麻酚,大麻二酚和大麻酚。仅在13.8%的样本中检测到THC。入院时从先前自我管理的烟熏大麻中获得最高的四氢大麻酚浓度(中位数1.4 ng / mL,范围0.3–113.6)。在推荐的药物滥用和精神卫生服务管理局(2 ng / mL)和在药物,酒精和药物影响下驾驶(DRUID)(1 ng / mL)的确证中,总共有2.5%和3.7%的样品THC阳性。分界线。目前,THC是唯一可用于监测OF中大麻暴露的分析物。但是,这些数据表明,目前的指南不太可能确定长期口服治疗性THC的施用和非法口服THC的使用。 THCCOOH的测量可以改善OF大麻素测试的检测和解释,并最大程度地减少被动吸入大麻烟污染OF的可能性。

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