Imbalance between Platelet Vascular Endothelial Growth Factor and Platelet-derived Growth Factor In Pulmonary Hypertension

摘要

Focal vascular injury and impaired endothelial function are fea - tures of pulmonary hypertension (PH) that lead to enhanced platelet endothelial cell interactions. Vascular endothelial growth factor (VEGF) is contained in platelets and released at sites of vas - cular injury to promote endothelial repair and wound healing in combination with platelet - derived nonspecific mitogens such as platelet - derived growth factor (PDGF).