Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice

摘要

Neutrophils play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). TO elu- cidate the possible involvement of neutrophil elastase (NE) in pulmonary fibrosis, we investigated the efficacy of a new specific NE inhibitor (NON-5064. Na) in a murine model of human IPF, bleomy- cin-induced pulmonary fibrosis. Bronchoalveolar lavage (BAL) and histopathological analysis were performed on bleomycin-treated mice (group A), bleomycin and NON-5064. Na-treated mice (group B), and saline control groups at 1, 15, and 29 d after the end of blemoycin treatment.