Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs

摘要

Keratinocyte growth factor (KGF) prevents α-naphthylthiourea (ANTU)-induced permeability edema ex vivo. To explore the mechanisms in this involved effect, we administered KGF (5 mg/kg, intratra- cheally) 48 h prior to ANTU (50 mg/kg, intraperitoneally). Several groups were studied: phosphate- buffered saline/dimethylsulfoxide (PBS/DMSO) (vehicles), PBS/ANTU, and KGF/ANTU. At 90 min af- ter ANTU injection the lungs were removed, ventilated, and perfused ex vivo for 180 min.0