Alveolar Macrophages from Atopic Asthmatics, But Not Atopic Nonasthmatics, enhance interleukin-5 Production by CD4+ T Cells

摘要

Recent studies have demonstrated that different antigen-presenting cell(APC)-related factors in the microenvironment of a T cell may determine its profile and quantity of cytokine expression and pro- duction. We have therefore examined the effects of alveolar macrophages and peripheral blood monocytes on interleukin(IL)-5 production by peripheral blood CD4+ T cells from atopic people with asthma(AA), atopic people without asthma(AN), and nonatopic normal subjects(N).