Langerhans cell histiocytosis following acute leukemia in an adult

摘要

To the editor: A 69-year-old man presents with cough and SOB approximatelyn3.5 years following diagnosis of a poorly differentiated acute lymphocyticnleukemia (progenitor cell phenotype). By flow cytometry, the initialnleukemia in 1998 was positive for HLA-DR, CD34, and CD45 and negativenfor lymphoid and myeloid markers including: CD3, CD5, CD7, CD19, CD10,nCD20, CD13, CD33, CD11b, and CD14; CD1a and S-100 protein stainingnwere not available on this sample. A pathologic diagnosis of a progenitorncell leukemia most suggestive of acute lymphocytic leukemia was made.nThe patient received induction therapy in November 1998 and achieved ancomplete remission. Consolidation therapy was discontinued after one cyclendue to severe cytopenias. Maintenance therapy was discontinued aftern6 months secondary to methotrexate-induced hepatoxicity.