Fludarabine, cyclophosphamide, anti-thymocyteglobulin, and low-dose total body irradiation conditioning enables 1-HLA-locus-mismatched hematopoietic stem cell transplantation for very severe aplastic anemia without affecting ovarian function

摘要

Allogeneic hematopoietic stem cell transplantation for severe aplastic anemia from an alternative donor isnassociated with higher risks of graft rejection and severe graft-versus-host disease. We developed a condi-ntioning regimen consisting of rabbit anti-thymocyte globulin, fludarabine, cyclophosphamide, and low-dosentotal body irradiation. Two adult female patients with transfusion-dependent very severe aplastic anemianunderwent 1-locus mismatched transplantation using this regimen. Both patients achieved stable engraft-nment and the clinical course thereafter was uneventful with persistently normal ovarian function. This novelnconditioning regimen may be suitable for alternative donor transplantation for severe aplastic anemia, espe-ncially in young female patients. Am. J. Hematol. 84:167–169, 2009. V V C 2008 Wiley-Liss, Inc.