Discontinuation Of 5% Alcohol In 5% Dextrose Injection: Implications For Antidote Stocking

摘要

In 2005, The Illinois Poison Center reported the lack of availability of 10% alcohol in 5% dextrose injection.1 The center wishes to inform health-system pharmacists of the discontinuation of 5% alcohol in 5% dextrose injection. The only manufacturer of this product (Hospira) stopped producing it in December 2007.rnFive percent alcohol in 5% dextrose injection is one of several treatment options used to manage ethylene glycol and methanol poisonings, as well as toxicity from other low-molecular-weight gly-cols. Other treatment options include administering 95% alcohol or 40% alcohol diluted in juice orally or via naso-gastric tube, preparing a 10% alcohol intravenous solution using absolute alcohol and 5% dextrose, or treatment with the alcohol dehydrogenase (ADH) inhibitor fomepizole. The discontinuation of 5% alcohol in 5% dextrose will most likely result in increased use of fomepizole.rnFomepizole exerts its effect through competitive inhibition of ADH and subsequent reduction of the toxic metabolites generated by the metabolism of ethylene glycol and methanol.