Reproductive History and Mortality in Late Middle Age among Norwegian Men and Women

Emily Grundy1 and Øystein Kravdal2

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Reproductive History and Mortality in Late Middle Age among Norwegian Men and Women

机译：挪威中世纪男女生殖史和死亡率

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There is growing recognition that reproductive patterns may have long-term health implications, although most evidence is restricted to women. The authors used register data to derive fertility histories for all Norwegian men and women born in 1935–1958. Discrete-time hazard modeling was used to analyze later-life mortality by aspects of reproductive history. A total of 63,312 deaths were observed during 14.5 million person-years of follow-up in 1980–2003, when subjects were aged 45–68 years. Models included detailed information on educational qualifications and marital status. Odds of death relative to those for subjects with two children were highest for the childless (women: odds ratio (OR) = 1.50, 95% confidence interval (CI): 1.43, 1.57; men: OR = 1.35, 95% CI: 1.30, 1.40) and next highest for those with only one child (women: OR = 1.31, 95% CI: 1.26, 1.37; men: OR = 1.20, 95% CI: 1.16, 1.24). Results for the parous showed a positive association between earlier parenthood and later mortality, a reverse association with late age at last birth, and an overall negative association between higher parity and mortality. The similarity of results for women and men suggests biosocial pathways underlying associations between reproductive history and health. The lack of any high-parity disadvantage suggests that in the “family friendly” Norwegian environment, the health benefits of having several children may outweigh the costs.

机译：人们越来越认识到，尽管大多数证据仅限于妇女，但生殖方式可能对健康产生长期影响。作者利用登记数据得出了1935年至1958年出生的所有挪威男性和女性的生育史。离散时间危害模型用于通过生殖史方面分析晚年死亡率。 1980-2003年，受试者年龄为45-68岁，在1450万人-年的随访中共观察到63,312例死亡。模型包括有关学历和婚姻状况的详细信息。相对于有两个孩子的受试者而言，死亡几率是无子女的最高（妇女：优势比（OR）= 1.50，95％置信区间（CI）：1.43，1.57；男性：OR = 1.35，95％CI：1.30 ，只有1.40），其次是只有一个孩子的女性（女性：OR = 1.31，95％CI：1.26，1.37；男性：OR = 1.20，95％CI：1.16，1.24）。父母的结果表明，较早的生育率和较高的死亡率之间呈正相关，与最后一次出生的晚期年龄呈负相关，而较高的性别和死亡率之间总体呈负相关。男女结果的相似性表明，生殖史与健康之间存在关联的生物社会途径。缺乏任何高度平等的劣势表明，在“家庭友好”的挪威环境中，生几个孩子的健康益处可能会超过代价。

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《American Journal of Epidemiology》 |2008年第3期|p.271-279|共9页
作者
Emily Grundy1 and Øystein Kravdal2;
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1Centre for Population Studies, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom 2Department of Economics, University of Oslo, Oslo, Norway;

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1. Reproductive history and mortality in late middle age among Norwegian men and women. [J] . Grundy E, Kravdal O American Journal of Epidemiology . 2008,第3期

机译：挪威男女中年晚期的生殖史和死亡率。
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4. Point-of-Care Assessment of Folate Status in Women of Reproductive Age Using a Fluorescence Lateral Flow Assay^* [C] . E. G. Rey, J. L. Finkelstein, D. Erickson Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：使用荧光侧向流分析法在育龄妇女叶酸状况的护理点评估^*
5. Family history of breast cancer in relation to breast cancer in women under age 45, as a modifier of other risk factors, and as a predictor of mortality. [D] . Malone, Kathleen E. 1993

机译：与45岁以下女性的乳腺癌相关的乳腺癌家族史，可作为其他危险因素的修正量，也可以作为死亡率的预测指标。
6. Educational inequalities in mortality over four decades in Norway: prospective study of middle aged men and women followed for cause specific mortality 1960-2000 [O] . 2010

机译：挪威四十年来死亡率的教育不平等：针对中年男女的前瞻性研究1960-2000年引起特定死亡率
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Reproductive History and Mortality in Late Middle Age among Norwegian Men and Women

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