Associations Between Anthropometry, Cigarette Smoking, Alcohol Consumption, and Non-Hodgkin Lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

摘要

Prospective studies of lifestyle and non-Hodgkin lymphoma (NHL) are conflicting, and some are inconsistentnwith case-control studies. The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was used tonevaluate risk of NHL and its subtypes in association with anthropometric factors, smoking, and alcohol consump-ntion in a prospective cohort study. Lifestyle was assessed via questionnaire among 142,982 male and femalenparticipants aged 55–74 years enrolled in the PLCO Trial during 1993–2001. Hazard ratios and 95% confidencenintervals were calculated using Cox proportional hazards regression. During 1,201,074 person-years of follow-upnthrough 2006, 1,264 histologically confirmed NHL cases were identified. Higher bodymass index (BMI; weight (kg)height (m)n2n) at ages 20 and 50 years and at baseline was associated with increased NHL risk (Ptrend < 0.01 for all;ne.g., for baseline BMI u000130 vs. 18.5–24.9, hazard ratio ¼ 1.32, 95% confidence interval: 1.13, 1.54). Smoking wasnnot associated with NHL overall but was inversely associated with follicular lymphoma (ever smoking vs. never:nhazard ratio ¼ 0.62, 95%confidence interval: 0.45, 0.85). Alcohol consumption was unrelated to NHL (drinks/week:nPtrend ¼ 0.187). These data support previous studies suggesting that BMI is positively associated with NHL, shownan inverse association between smoking and follicular lymphoma (perhaps due to residual confounding), and donnot support a causal association between alcohol and NHL.