Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

Y. González-Lama; F. Bermejo; A. López-Sanromán; V. García-Sánchez; M. Esteve; J. L. Cabriada; A. G. McNicholl; R. Pajares; F. Casellas; O. Merino; D. Carpio; M. I. Vera; C. Mu?oz; M. Calvo; L. M. Benito; L. Bujanda; F. J. García-Fernández; E. Ricart; D. Ginard; M. Velasco; J. A. Carneros; N. Mance?ido; M. Calvo; A. Algaba; C. Froilan; C. Cara; J. Maté; L. Abreu; J. P. Gisbert; on behalf of Grupo Espa?ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU)

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Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

机译：硫嘌呤甲基转移酶活性和硫唑嘌呤代谢产物浓度不能预测硫嘌呤治疗的炎症性肠病患者的临床结局

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Aliment Pharmacol Ther 2011; 34: 544–554

机译：Aliment Pharmacol Ther 2011； 34：544–554

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《Alimentary Pharmacology & Therapeutics》 |2011年第5期|544-554|共11页
作者
Y. González-Lama; F. Bermejo; A. López-Sanromán; V. García-Sánchez; M. Esteve; J. L. Cabriada; A. G. McNicholl; R. Pajares; F. Casellas; O. Merino; D. Carpio; M. I. Vera; C. Mu?oz; M. Calvo; L. M. Benito; L. Bujanda; F. J. García-Fernández; E. Ricart; D. Ginard; M. Velasco; J. A. Carneros; N. Mance?ido; M. Calvo; A. Algaba; C. Froilan; C. Cara; J. Maté; L. Abreu; J. P. Gisbert; on behalf of Grupo Espa?ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU);
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La Princesa and Instituto de Investigación Sanitaria Princesa (IP) Madrid Spain.;

Puerta de Hierro Madrid Spain.;

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) Spain.;

Fuenlabrada Madrid Spain.;

Ramón y Cajal Madrid Spain.;

Reina Sofía Córdoba Spain.;

Mutua de Terrasa Barcelona Spain.;

Galdakao Vizcaya Spain.;

La Paz Madrid Spain.;

Vall d`Hebron Barcelona Spain.;

Cruces Bilbao Spain.;

Montecelo Pontevedra Spain.;

San Eloy Vizcaya Spain.;

Virgen del Toro Menorca Spain.;

Donostia San Sebastián Spain.;

San Juan de Dios del Aljarafe Sevilla Spain.;

Clínic Barcelona Spain.;

Son Dureta Mallorca Spain.;

Alto Deba Guipúzcoa Spain.;

UCB Pharma Madrid Spain.;

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1. Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients. [J] . Gonzalez Lama Y, Bermejo F, Lopez Sanroman A, Alimentary pharmacology & therapeutics. . 2011,第5期

机译：硫嘌呤甲基转移酶活性和硫唑嘌呤代谢产物浓度不能预测硫嘌呤治疗的炎症性肠病患者的临床结局。
2. IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. [J] . Haglund S, Taipalensuu J, Peterson C, British Journal of Clinical Pharmacology . 2008,第1期

机译：硫代嘌呤治疗的炎症性肠病患者的IMPDH活性-与TPMT活性和代谢产物浓度有关。
3. IMPDH activity in thiopurine-treated patients with inflammatory bowel disease – relation to TPMT activity and metabolite concentrations [J] . Sofie Haglund, Jan Taipalensuu, Curt Peterson, British journal of clinical pharmacology . 2008,第1期

机译：硫嘌呤治疗的炎症性肠病患者的IMPDH活性-与TPMT活性和代谢产物浓度的关系
4. Can we prevent inflammatory bowel disease-related colorectal cancer with 5-aminosalicylic acid, azathioprine, or 6-mercaptopurine? The clinical evidence [C] . F. S. VELAYO Falk Symposium . 2007

机译：我们可以防止炎症性肠病相关结直肠癌，用5-氨基水杨酸，偶氮嘌呤或6-巯基嘌呤吗？临床证据
5. Oxidation Status as a Predictor of Disease Activity and Response to Therapy in Pediatric Patients with Inflammatory Bowel Disease [D] . Ajithkumar, Aravindh K. 2020

机译：氧化地位作为疾病活动的预测因素，对炎症性肠病儿科患者的疗法响应
6. IMPDH activity in thiopurine-treated patients with inflammatory bowel disease – relation to TPMT activity and metabolite concentrations [O] . Sofie Haglund, Jan Taipalensuu, Curt Peterson, 2008

机译：硫嘌呤治疗的炎症性肠病患者的IMPDH活性-与TPMT活性和代谢产物浓度的关系
7. Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients [O] . Y. González-Lama, F. Bermejo, A. López-Sanromán, 2011

机译：硫嘌呤甲基转移酶活性和氮素代谢物浓度不会预测硫嘌呤治疗的炎症性肠病患者的临床结果

Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

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