Targeting Gold Nanoshells on Silica Nanorattles: a Drug Cocktail to Fight Breast Tumors via a Single Irradiation with Near-Infrared Laser Light

摘要

One of the current challenges in biomedicine is to develop safe and effective nanomedicines for selective tumor therapy.Recently, near-infrared (NIR) light absorbing plasmonic nanomaterials have attracted intensive attention for their hyper-themia therapy to kill tumorigenic cells without damaging normal cells, such as gold nanorods, gold nanocages,Au_xAg_(1-x). dendrites, gold nanoshells on polystyrene spheres, assembled gold nanoparticles and many multifunctional nanocomposites, Our previous study reported a novel material of gold nanoshells on drug-loaded silica nanorattles which can combine the hyperthermia with chemotherapy to optimize cancer therapy whose synergistic effects are greater than the two individual treatments alone. Despite the successful application of many gold-based NIR absorbing materials in cancer therapy, most studies of them rely on the passive targeting effect (the so-called enhanced permeability and retention, EPR effect) to direct nanocarriers at tumor sites through the enhanced permeability of tumor vasculature and the decreased draining efficacy of tumor lymphatics.