Bioprocessing Device Composed of Protein/DNA/Inorganic Material Hybrid

摘要

Major challenges in molecular electronics include miniaturization, and the realization of a simple function to alter silicon-based electronics. It has been hard to develop a single molecular-based computing system, since such systems need complex functionality to be developed at the single-molecular level. To develop a molecular-based biocomputing system, a bioprocessing device is demonstrated that consists of recombinant azurin/DNA/inorganic material hybrid to perform the various functions in a device. A metalloprotein which exhibits redox behavior is used as a biomemory source. The redox property could be controlled with command materials (conducting nano-particles, heavy metal ions, and semiconducting nanoparticles) to perform 'information reinforcement,' 'information regulation,' and 'information amplification' functions, respectively. This bioprocessing device could be a foundation to develop single-biomolecular-based computing systems.