Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats

摘要

Conclusion: NBP pre-treatment or post- treatment markedly enhanced the rCBF to striatum in RMCAO rats. Aim: To study the effect of dl-3-n-butylphthalide (NBP)on regional cerebral blood flow(rCBF)in forcal cerebral ischemia rats. Methods: in chloral hydrate-anethetized rat, the proximal portion of right middle cerebral artery(RMCA)was occluded, and H_2 needle electrode was implanted in right striatum. rCBF was monitored in striatum using hydrogen clearance method. Results: ten min after RMCA occlusion(RMCAO), NBP(5,10,20 mg.kg~-1 ip) markedly increased rCBF to striatum(P < 0.01).