Effects of excitatory amino acids and nimodipine on calcium currents in cultured rat cortical neurons

摘要

AIM: To study the effect of excitatory amino acid (EAA) and calcium channel blocker on neuronal calcium channels. METHODS: With patch-clamp technique (whole-cell recording), the effects of Bay-K- 8644, cesium glutamate, potassium aspartate, and nimodipine (Nim) on calcium currents (I_Ca) in cultured cortical neurons of neonatal rats were studied. CONCLUSION: EAA had increasing effects On neuronal calcium currents and Nim inhibited Ca~2+ Influx in neurons.