Kanglemycin C vs ciclosporin on immunosuppression in mice

摘要

AIM: To study inhibitory effects of kanglemycin C (Kan) on the mouse immune system, and Compare with the effects of ciclosporin (Cic). METHODS: Delayed hypersensitivity (DH) and Cyclophosphamide-potentiated DH induced by Dinitrofluorobenzene (DNFB); heart allograft and Skin allograft; hemolysin; the phagocytosis of the Pritoneal macrophage. CONCLUSION: Kan had marked suppressive effects On cell-mediated and humoral-mediated immune Responses, but no effect on phagocytosis of Macrophage.