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Review: Moderate weight loss improves functional disability but does not reduce pain in obese patients with knee osteoarthritis

机译:评论:适度的体重减轻可改善功能障碍,但不能减轻肥胖的膝骨关节炎患者的疼痛

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摘要

Obesity is a clearly established risk factor for knee osteoarthritis. Thenmeta-analysis by Christensen and colleagues, which examined the relationnbetween weight loss and knee symptoms, was limited by the smallnnumber of studies that met criteria for methodological quality. Thenincluded studies were heterogeneous with respect to the interventionnand amount of weight lost; the largest amount of differential weightnloss was 6.7 kg, and in 2 of 5 studies, the control and interventionngroups did not differ for weight loss. Despite these limitations, thenmeta-analysis was able to show that weight loss > 5% improves kneendisability, and the effect size suggests that this result is clinically meaningful.
机译:肥胖是膝盖骨关节炎的明确危险因素。 Christensen及其同事进行的nmeta分析检查了体重减轻与膝关节症状之间的关系,但该方法的研究数量很少,但符合方法学质量标准的研究却很少。然后,所包括的研究在干预措施和体重减轻方面是异质的。体重差异最大的是6.7 kg,在5个研究中的2个中,对照组和干预组的体重减轻没有差异。尽管有这些局限性,nmeta分析仍然能够表明体重减轻> 5%可以改善膝关节残疾,并且效果大小表明该结果在临床上具有重要意义。

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  • 来源
    《ACP Journal Club》 |2007年第2期|p.43-43|共1页
  • 作者单位

    Sunnybrook Health Sciences Centre, University of TorontoToronto, Ontario, Canada;

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  • 正文语种 eng
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