Celecoxib combined with esomeprazole prevented recurrent ulcer bleeding in patients with previous NSAID-induced ulcer bleeding

摘要

The highest incidence of GI complications associated with NSAID usenoccurs in patients who have had prior GI bleeding or prior complicatednor uncomplicated ulcer; are > 75 years of age; and those taking concomitantnclopidogrel, warfarin, steroids, or other NSAIDs. CombiningnASA with a PPI reduces bleeding compared with placebo (1) or clopidogrelnalone (0.7% vs 8.6%, P = 0.001) (2). However, neither combiningndiclofenac with omeprazole nor using celecoxib alone is sufficientlyneffective for preventing recurrent bleeding from NSAIDs (4.9% vsn6.4%, P = 0.6) (3).