10-year risk for CV events was 10% to 56% in rheumatoid arthritis; risk was greatest for patients with CV risk factors

摘要

In patients with rheumatoid arthritis (RA), what is the 10-year absolute risk for cardiovascular (CV) events? How do CV risk factors affect absolute risk? nnMethodsnnDesign: Inception cohort followed for median 15 years.nnSetting: Rochester Epidemiology Project medical records linkage system in Olmsted County, Minnesota, USA.nnPatients: 553 adults 18 years of age (mean age 57 y, 73% women) who had RA (4 of 7 American College of Rheumatology 1987 criteria) and were newly diagnosed between 1955 and 1994. For comparison, 574 adults without RA, matched for sex, year of birth, and length of medical history, were randomly selected from the same record system. Patients with a history of CV disease at baseline were excluded.nnPrognostic factors: Traditional CV risk factors (cigarette smoking, dyslipidemia, diabetes mellitus, hypertension, and obesity [body mass index 30 kg/m2]) and low body mass index (< 20 kg/m2).nnOutcomes: Composite of coronary revascularization procedure (including percutaneous transluminal coronary angioplasty and coronary artery bypass graft), silent or nonfatal myocardial infarction, congestive heart failure, or CV death.