Effects of modulated LDLs on the release of endothelin-1 And prostacyclin by endothelial cells in culture

摘要

Objective To study the releases of endothelin-1 and prostacyclin by endothelial cells in culture and to elucidate how these releases were influenced by smoke-treated low density lipoprotein. Methods We exposed en- dothelial cell cultures to native or oxidized low density lipoproteins, low density lipoproteins treated by dimethlsul- foxide-soluble particles form cigarette smoke or dimethylsulfoxide alones. The release of endothelin-1 was assayed by bioassay and the release of prostacyclin was assayed by radioimmunoassay.