Merging Gold and Organocatalysis: A Facile Asymmetric Synthesis of Annulated Pyrroles

摘要

The combination of cinchona-alkaloid-derived primary amine and Au^I–phosphine catalysts allowed the selective C—H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities.