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Ethics of Mitochondrial Replacement Techniques: A Habermasian Perspective

机译:线粒体置换技术的伦理学:哈贝马斯的观点

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摘要

Jürgen Habermas is regarded as a central bioconservative commentator in the debate on the ethics of human prenatal genetic manipulations. While his main work on this topic, The Future of Human Nature, has been widely examined in regard to his position on prenatal genetic enhancement, his arguments regarding prenatal genetic therapeutic interventions have for the most part been overlooked. In this work I do two things. First, I present the three necessary conditions that Habermas establishes for a prenatal genetic manipulation to be regarded as morally permissible. Second, I examine if mitochondrial replacement techniques meet these necessary conditions. I investigate, specifically, the moral permissibility of employing pronuclear transfer and maternal spindle transfer. I conclude that, according to a Habermasian perspective on prenatal genetic manipulation, maternal spindle transfer (without using a preselected sperm and egg) and pronuclear transfer are morally impermissible. Maternal spindle transfer is, in principle, morally permissible, but only when we have beforehand preselected a sperm and an egg for our reproductive purpose. These findings are relevant for bioconservatives, both for those who hold a Habermasian stance and for those who hold something akin to a Habermasian stance, because they answer the question: what should bioconservatives do regarding mitochondrial replacement techniques? In fact, the answer to this question does not only normatively prescribe what bioconservatives should do in terms of their personal morality, but it also points towards what kind of legislation regulating mitochondrial replacement techniques they should aim at.
机译:于尔根·哈贝马斯(JürgenHabermas)在有关人类产前基因操作伦理的辩论中被视为主要的生物保守性评论员。尽管就其在产前基因增强方面的立场对他在该主题上的主要著作《人性的未来》进行了广泛检查,但有关产前基因治疗干预的论点在大多数情况下却被忽略了。在这项工作中,我做两件事。首先,我介绍了哈贝马斯确立的三个必要条件,以使产前基因操作在道德上被允许。其次,我检查线粒体替代技术是否满足这些必要条件。我专门研究采用核前转移和母体主轴转移的道德允许性。我得出结论,根据哈贝马斯关于产前遗传操作的观点,从道德上讲,母亲纺锤体转移(不使用预选的精子和卵子)和核前转移是不允许的。从原则上讲,母体纺锤体转移在道德上是允许的,但前提是我们事先已为生殖目的预先选择了精子和卵子。这些发现对于持有Habermasian立场的人和持有类似于Habermasian立场的人的生物防腐剂都具有重要意义,因为他们回答了这个问题:对于线粒体替代技术,生物防腐剂应该做什么?实际上,这个问题的答案不仅规范地规定了生物保守剂应根据其个人道德行事的方式,而且还指出了应针对何种法律规范线粒体替代技术。

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