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Prognostic value of intra‐tumoral CD8+/FoxP3+ lymphocyte ratio in patients with resected colorectal cancer liver metastasis

机译：肿瘤内CD8 + / FoxP3 +淋巴细胞比例在结直肠癌切除肝转移患者中的预后价值

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Background and ObjectivesPatients with isolated colorectal‐cancer‐liver‐metastases (CRCLM) frequently undergo metastatectomy. Tumor‐infiltrating‐lymphocytes (TILs) have prognostic potential in the setting of primary colorectal cancer, however, their role in CRCLM is less studied. We aimed to study the spatial distribution and prognostic role of tumor‐infiltrating CD8⁺ cytotoxic T‐cells and FoxP3⁺ regulatory T‐cells at the metastatic site of CRCLM patients.

机译：背景和目的患有孤立性结直肠癌-肝转移（CRCLM）的患者经常接受转移癌切除术。肿瘤浸润淋巴细胞（TILs）在原发性结直肠癌的发生中具有预后的潜力，但是，它们在CRCLM中的作用研究较少。我们旨在研究在CRCLM患者转移部位肿瘤浸润性CD8 ^{+ 细胞毒性T细胞和FoxP3 ^{+ 调节性T细胞的空间分布和预后作用。}}

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期刊名称 Wiley-Blackwell Online Open
作者
Kostandinos Sideras; Boris Galjart; Angela Vasaturo; Alexander Pedroza‐Gonzalez; Katharina Biermann; Shanta Mancham; Alex L. Nigg; Bettina E. Hansen; Hans A. Stoop; Guoying Zhou; Cornelis Verhoef; Stefan Sleijfer; Dave Sprengers; Jaap Kwekkeboom; Marco J. Bruno;
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年(卷),期 -1(118),1
年度 -1
页码 68–76
总页数 9
原文格式 PDF
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关键词
biomarkers colorectal cancer FoxP3 metastasis tumor infiltrating lymphocytes;

机译：生物标志物;大肠癌;FoxP3;转移;肿瘤浸润淋巴细胞;

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专利

1. Prognostic value of intra‐tumoral CD8 + + /FoxP3 + + lymphocyte ratio in patients with resected colorectal cancer liver metastasis [J] . Sideras Kostandinos, Galjart Boris, Vasaturo Angela, Journal of Surgical Oncology . 2018 ,第1期

机译：患有切除结肠直肠癌肝转移的患者肿瘤内CD8 + + / FoxP3 + +淋巴细胞比例的预后价值
2. Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study [J] . Minoru Miyashita, Hironobu Sasano, Kentaro Tamaki, Breast Cancer Research . 2015 ,第1期

机译：三阴性乳腺癌新辅助化疗后残留肿瘤中浸润性CD8 + 和FOXP3 + 淋巴细胞的预后意义以及这些参数的改变：一项回顾性多中心研究
3. The intratumoural subsite and relation of CD8+ and FOXP3+ T lymphocytes in colorectal cancer provide important prognostic clues [J] . A Ling, S Edin, M L Wikberg, British Journal of Cancer . 2014 ,第10期

机译：大肠癌的肿瘤内亚位及其与CD8 +和FOXP3 + T淋巴细胞的关系提供了重要的预后线索
4. Comparison of AdaBoost and Logistic Regression for Detecting Colorectal Cancer Patients with Synchronous Liver Metastasis [C] . Jingran Wen, Xiaoyan Zhang, Ye Xu, International Conference on Biomedical and Pharmaceutical Engineering . 2009

机译：adaBoost和Logistic回归检测同步肝转移的结直肠癌患者的比较
5. A link between TGFbeta and intraepithelial tumor infiltrating lymphocytes in microsatellite instability-high colorectal cancer. [D] . Baker, Kristi Dorothy. 2008

机译：TGFbeta和微卫星不稳定性高结直肠癌中上皮内肿瘤浸润淋巴细胞之间的联系。
6. Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study [O] . Minoru Miyashita, Hironobu Sasano, Kentaro Tamaki, 2015

机译：三阴性乳腺癌新辅助化疗后残留肿瘤中浸润性CD8 +和FOXP3 +淋巴细胞的预后意义以及这些参数的改变：一项回顾性多中心研究
7. The Prognostic Significance of the Tumor-infiltrating Programmed Cell Death-1+ to CD8+ Lymphocyte Ratio in Patients with Colorectal Cancer [O] . 2017

机译：肿瘤浸润的细胞死亡-1 +至CD8 +淋巴细胞比与结肠直肠癌患者的预后意义

Prognostic value of intra‐tumoral CD8+/FoxP3+ lymphocyte ratio in patients with resected colorectal cancer liver metastasis

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