Prospective PED-study of intravitreal aflibercept for refractory vascularized pigment epithelium detachment due to age-related macular degeneration: morphologic characteristics of non-responders in optical coherence tomography

摘要

( and ) Two exemplary patients of group 1 both with a vascular pigment epithelium detachment (vPED) lesion showing persistence of subretinal fluid throughout 1 year of treatment. Patient 1 ( ) and patient 2 ( ) first row baseline visit, second row 6-month visit, and third row 12-month visit baseline visit. Note the increase in hyperreflectivity in the sub-RPE space in the course of the treatment, while the subretinal fluid at the edge of the vPED lesion persists throughout the treatment. ( ) Exemplary patient of group 2 with a vPED lesion showing complete resolution of subretinal fluid after the fourth injection. First row baseline visit, second row 3-month visit, and third row 4-month visit