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Disability and all-cause mortality in the older population: evidence from the English Longitudinal Study of Ageing

机译:老年人口中的残疾和全因死亡率:英国衰老纵向研究的证据

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摘要

Despite the vast body of literature studying disability and mortality, evidence to support their association is scarce. This work investigates the role of disability in explaining all‐cause mortality among individuals aged 50+ who participated in the English Longitudinal Study of Aging. The aim is to explain the gender paradox in health and mortality by analysing whether the association of disability with mortality differs between women and men. Disability was conceived following the International Classification of Functioning, Disability and Health (ICF), proposed by the WHO, that conceptualizes disability as a combination of three components: impairment, activity limitation and participation restriction. Latent variable models were used to identify domain-specific factors and general disability. The association of the latter with mortality up to 10 years after enrolment was estimated using discrete-time survival analysis. Our work confirms the validity of the ICF framework and finds that disability is strongly associated with mortality, with a time-varying effect among men, and a smaller constant effect for women. Adjusting for demographic, socioeconomic and behavioural factors attenuated the association for both sexes, but overall the effects remained high and significant. These findings confirm the existence of gender paradox by showing that, when affected by disability, women survive longer than men, although if men survive the first years they appear to become more resilient to disability. Sensitivity analyses suggested that the gender paradox cannot be solely explained by gender-specific health conditions: there must be other mechanisms acting within the pathway between disability and mortality that need to be explored.Electronic supplementary materialThe online version of this article (doi:10.1007/s10654-016-0160-8) contains supplementary material, which is available to authorized users.
机译:尽管有大量研究残疾和死亡率的文献,但缺乏支持它们联系的证据。这项工作调查了残疾在解释50岁以上参加英语纵向纵向研究的个人中全因死亡率中的作用。目的是通过分析残疾与死亡率之间的关联在男女之间是否存在差异,来解释健康和死亡率方面的性别悖论。世卫组织提出的《国际功能,残疾与健康分类》(ICF)将残疾概念化为三个组成部分:残疾,活动限制和参与限制。潜在变量模型用于识别领域特定因素和一般残疾。使用离散时间生存分析估计了后者与入组后长达10年的死亡率的关系。我们的工作证实了ICF框架的有效性,并发现残疾与死亡率密切相关,在男性中随时间变化的影响与对女性的持续影响较小。对人口,社会经济和行为因素进行调整后,男女双方的关联性均减弱,但总体而言,影响仍然很大。这些发现证实了性别悖论的存在,表明当受到残疾影响时,妇女的生存时间比男性长,尽管如果男性在头几年生存,他们似乎对残疾的适应力就会增强。敏感性分析表明,性别悖论不能仅通过性别特定的健康状况来解释:在残疾与死亡率之间的途径中必须探索其他机制。电子补充材料本文的在线版本(doi:10.1007 / s10654-016-0160-8)包含补充材料,授权用户可以使用。

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