Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine Midazolam Warfarin Dextromethorphan Omeprazole Rosuvastatin and Digoxin in Phase 1 Studies in Healthy Subjects

摘要

IntroductionObeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug–drug interaction effect of OCA on metabolic CYP450 enzymes and drug transporters.