The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression

摘要

BackgroundThe neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion.