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Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse

机译：白介素-1 /白介素-1受体拮抗剂平衡的改变调节小鼠心肌梗塞后的心脏重塑。

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BackgroundHealing after acute myocardial infarction (AMI) is characterized by an intense inflammatory response and increased Interleukin-1 (IL-1) tissue activity. Genetically engineered mice lacking the IL-1 receptor (IL-1R1-/-, not responsive to IL-1) or the IL-1 receptor antagonist (IL-1Ra, enhanced response to IL-1) have an altered IL-1/IL-1Ra balance that we hypothesize modulates infarct healing and cardiac remodeling after AMI.

机译：背景急性心肌梗塞（AMI）后的愈合以强烈的炎症反应和增加的白介素1（IL-1）组织活性为特征。缺少IL-1受体（IL-1R1-/-，对IL-1无反应）或IL-1受体拮抗剂（IL-1Ra，对IL-1增强反应）的基因工程小鼠的IL-1 /我们假设的IL-1Ra平衡可调节AMI后的梗死愈合和心脏重塑。

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期刊名称 PLoS Clinical Trials
作者
Antonio Abbate; Fadi N. Salloum; Benjamin W. Van Tassell; Elena Vecile; Stefano Toldo; Ignacio Seropian; Eleonora Mezzaroma; Aldo Dobrina;
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年(卷),期 2011(6),11
年度 2011
页码 e27923
总页数 7
原文格式 PDF
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专利

1. Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction. [J] . van-Minkelen R, Wettinger SB, de-Visser MC, Atherosclerosis . 2009 ,第1期

机译：白介素1受体拮抗剂基因的单倍型，白介素1受体拮抗剂mRNA水平和心肌梗塞的风险。
2. Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse [J] . ToldoS., MezzaromaE., VanTassellB.W., Experimental Physiology . 2013 ,第3期

机译：白介素-1β阻滞剂可改善心肌梗死后的心脏重塑，而不会干扰小鼠的炎症小体
3. Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells. [J] . Maekawa Y, Mizue N, Chan A Circulation: An Official Journal of the American Heart Association . 2009 ,第14期

机译：心肌梗死后的存活和心脏重塑主要取决于宿主固有的免疫白介素1受体相关激酶4信号传导：骨髓来源的树突状细胞的调节剂。
4. Comparative study of recombinant human interleukin-1 receptor antagonist for the treatment of patients with psoriatic and rheumatoid arthrites [C] . Ischenko A., Kleymenova I., Raymuev K., Joint Conferences of the International Cytokine Society and the International Society for Interferon and Cytokine Research . 2011

机译：重组人白细胞介素-1受体拮抗剂治疗银屑病和类风湿性术患者的比较研究
5. Microparticles for Sustained Systemic or Local Delivery of Active Interleukin-1 Receptor Antagonist [D] . Clements, Anna E. B. 2018

机译：用于持续全身或局部递送活性白细胞介素-1受体拮抗剂的微粒
6. Interleukin-1β blockade improves cardiac remodeling after myocardial infarction without interrupting the inflammasome in the mouse [O] . Stefano Toldo, Eleonora Mezzaroma, Benjamin W. Van Tassell, -1

机译：白细胞介素-1β阻断在心肌梗塞后改善心脏重塑而不会中断小鼠中的炎症
7. Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse [O] . Abbate, Antonio, Salloum, Fadi N., Van Tassell, Benjamin W., 2011

机译：白介素-1 /白介素-1受体拮抗剂平衡的改变调节小鼠心肌梗塞后的心脏重塑。

Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse

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