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Reduction Theories Elucidate the Origins of Complex Biological Rhythms Generated by Interacting Delay-Induced Oscillations

机译:归约理论阐明了相互作用的延迟诱导振荡产生的复杂生物节律的起源。

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摘要

Time delay is known to induce sustained oscillations in many biological systems such as electroencephalogram (EEG) activities and gene regulations. Furthermore, interactions among delay-induced oscillations can generate complex collective rhythms, which play important functional roles. However, due to their intrinsic infinite dimensionality, theoretical analysis of interacting delay-induced oscillations has been limited. Here, we show that the two primary methods for finite-dimensional limit cycles, namely, the center manifold reduction in the vicinity of the Hopf bifurcation and the phase reduction for weak interactions, can successfully be applied to interacting infinite-dimensional delay-induced oscillations. We systematically derive the complex Ginzburg-Landau equation and the phase equation without delay for general interaction networks. Based on the reduced low-dimensional equations, we demonstrate that diffusive (linearly attractive) coupling between a pair of delay-induced oscillations can exhibit nontrivial amplitude death and multimodal phase locking. Our analysis provides unique insights into experimentally observed EEG activities such as sudden transitions among different phase-locked states and occurrence of epileptic seizures.
机译:已知时间延迟会在许多生物系统(如脑电图(EEG)活动和基因调控)中引起持续振荡。此外,延迟引起的振荡之间的相互作用会产生复杂的集体节奏,这些节奏起着重要的功能作用。然而,由于它们固有的无限维,相互作用延迟引起的振荡的理论分析受到限制。在这里,我们证明了有限维极限环的两种主要方法,即霍夫分支附近的中心流形减少和弱相互作用的相位减少,可以成功地应用于相互作用的无限维延迟诱发的振动。对于一般的相互作用网络,我们系统地推导了复杂的Ginzburg-Landau方程和相位方程,没有延迟。基于简化的低维方程,我们证明了一对延迟引起的振荡之间的扩散(线性吸引)耦合可以表现出不平凡的振幅衰减和多峰锁相。我们的分析为实验观察到的脑电活动提供了独特的见解,例如不同锁相状态之间的突然转变和癫痫发作的发生。

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