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The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53

机译：需要p300的C / H3域来保护VRK1和VRK2免受p53引起的下调

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BackgroundThe vaccinia-related kinase 1 (VRK1) protein, an activator of p53, can be proteolytically downregulated by an indirect mechanism, which requires p53-dependent transcription.

机译：背景痘苗相关激酶1（VRK1）蛋白是p53的激活剂，可以通过间接机制进行蛋白水解下调，该机制需要p53依赖性转录。

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期刊名称 PLoS Clinical Trials
作者
Alberto Valbuena; Sandra Blanco; Francisco M. Vega; Pedro A. Lazo;
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年(卷),期 2008(3),7
年度 2008
页码 e2649
总页数 11
原文格式 PDF
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专利

1. Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells. [J] . D Kalman, K Whittaker, J M Bishop, Molecular biology of the cell . 1993,第4期

机译：结合p105Rb，p130和p300的E1A域需要阻止PC12细胞中神经生长因子诱导的神经突生长。
2. Drosophila p53 Is Required to Increase the Levels of the dKDM4B Demethylase after UV-induced DNA Damage to Demethylate Histone H3 Lysine 9 [J] . Zoraya Palomera-Sanchez, Alyeri Bucio-Mendez, Viviana Valadez-Graham, The Journal of biological chemistry . 2010,第期

机译：在UV诱导的DNA损伤对去甲基化物组蛋白H3赖氨酸9后，需要增加DKDM4B脱甲基酶的水平。
3. The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3 [J] . Zhang Yi, Xue Yongming, Shi Jiejun, Nature structural & molecular biology . 2018,第9期

机译：P300的ZZ结构域介导相邻帽子结构域的特异性组蛋白H3
4. Visible-light-induced tenfold reduction of the electric field required for ferroelectric domain nucleation in MgO-doped lithium niobate [C] . Valdivia, C.E., Sones, . 2005

机译：MgO掺杂铌酸锂中可见光诱导的铁电畴成核所需电场的十倍减小
5. The HTLV-1 oncoprotein Tax and the tumor suppressorp53 bind a common domain of CBP/p300 to mediate transcriptional activation. [D] . Scoggin, Kirsten Elizabeth Strickler. 2003

机译：HTLV-1癌蛋白Tax和肿瘤抑制因子p53结合CBP / p300的共同结构域来介导转录激活。
6. Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway [O] . Alberto Valbuena, Susana Castro-Obregón, Pedro A. Lazo 2009

机译：自噬途径介导p53对DNA损伤的vRK1下调。
7. The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53 [O] . Valbuena, A., Blanco, Sandra, Vega, Francisco M., 2008

机译：需要p300的C / H3域来保护VRK1和VRK2免受p53引起的下调

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53

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