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1351. In vitro Activity of Cefiderocol (S-649266) a Siderophore Cephalosporin Against Enterobacteriaceae With Defined Extended-Spectrum Β-Lactamases and Carbapenemases

机译：1351.头孢洛考（S-649266）一种铁载体头孢菌素对肠杆菌科细菌具有确定的广谱β-内酰胺酶和碳青霉烯酶的体外活性

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BackgroundCefiderocol is a novel siderophore cephalosporin targeted for activity against carbapenem and multidrug-resistant Gram-negative species, including extended-spectrum β-lactamase (ESBL) and carbapenemase-producing strains. The Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE) is a federally funded, prospective multi-center consortium of 20 hospitals from nine US healthcare systems to track carbapenem-resistant Enterobacteriaceae.

机译：背景头孢地洛尔是一种新型的铁载体头孢菌素，目标是针对碳青霉烯和具有多重耐药性的革兰氏阴性菌，包括广谱β-内酰胺酶（ESBL）和产生碳青霉烯酶的菌株。克雷伯菌属和其他肠杆菌科对碳青霉烯类耐药性联合会（CRACKLE）是由美国9个医疗系统的20家医院组成的联邦资助，预期的多中心联合体，用于追踪耐碳青霉菌的肠杆菌科。

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期刊名称 Oxford Open
作者
Michael R Jacobs; Ayman M Abdelhamed; Caryn E Good; Daniel D Rhoads; Kristine M Hujer; Andrea M Hujer; T Nicholas Domitrovic; Susan D Rudin; Sandra S Richter; David Van Duin; Barry N Kreiswirth; Robert A Bonomo;
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年(卷),期 -1(5),Suppl 1
年度 -1
页码 S413–S414
总页数 2
原文格式 PDF
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1. ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum beta-Lactamases and Carbapenemases [J] . Jacobs Michael R., Abdelhamed Ayman M., Good Caryn E., Antimicrobial agents and chemotherapy. . 2019,第1期

机译：Argonaut-I：Cefiderocol（S-649266）的活性，抗革兰阴孢子素，抗革兰阴孢子素，包括耐鲤鱼抗性的诸如肠杆菌的β-内酰胺酶和碳基氨酸酶和肠杆菌酶
2. Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship [J] . Toshiaki Aoki, Hidenori Yoshizawa, Kenji Yamawaki, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：Cefiderocol（S-649266），一种新的剑隆头孢菌素，其表现出对铜绿假单胞菌和其他革兰阴性病原体的有效活性，包括多药物抗菌细菌：结构活动关系
3. In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains [J] . Kohira Naoki, West Joshua, Ito Akinobu, Antimicrobial agents and chemotherapy. . 2016,第2期

机译：铁载体头孢菌素S-649266对肠杆菌科临床分离株（包括耐碳青霉烯的菌株）的体外抗菌活性。
4. Prevalence of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae with Focus on the Molecular Characterization of ESBL- and AmpC β-Lactamase-Producing Escherichia coli Isolated in Canadian Hospitals from 2005-2009 [D] . Simner, Patricia Jeanne 2011

机译：2005-2009年在加拿大医院分离的产广谱β-内酰胺酶肠杆菌的流行情况，侧重于生产ESBL和AmpCβ-内酰胺酶的大肠杆菌的分子表征
5. ARGONAUT-I: Activity of Cefiderocol (S-649266) a Siderophore Cephalosporin against Gram-Negative Bacteria Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases [O] . Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, 2019

机译：ARGONAUT-I：头孢呋咯酯（S-649266）（一种铁载体头孢菌素）对革兰氏阴性细菌的活性包括耐碳青霉烯类的非发酵菌和肠杆菌科（具有明确的广谱β-内酰胺酶和碳青霉烯酶）
6. 1297. In-Vitro Antibacterial Activities of Cefiderocol (S-649266) Alone and With the Addition of Beta-Lactamase Inhibitors Against Multidrug-resistant Acinetobacter baumannii [O] . Jacinda C Abdul-Mutakabbir, Logan Nguyen, Philip Maassen, 2020

机译：1297.单独的Cefiderocol（S-649266）的体外抗菌活性，并加入β-内酰胺酶抑制剂对多药抗性抗血管杆菌Baumannii

1351. In vitro Activity of Cefiderocol (S-649266) a Siderophore Cephalosporin Against Enterobacteriaceae With Defined Extended-Spectrum Β-Lactamases and Carbapenemases

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