244. Impact of Antibiotic Susceptibility Reporting on Broad-Spectrum Antibiotic Use in Serratia and Morganella Bacteremia

摘要

BackgroundThe increase in antibiotic resistance highlights the necessity of antimicrobial stewardship strategies to guide antibiotic de-escalation. Retrospective data suggest noninferior outcomes with carbapenem-sparing regimens in AmpC-β-lactamase producing Serratia marcescens and Morganella morganii bacteremia. To minimize broad-spectrum (BS) antibiotic use, our microbiology laboratory recently changed the antibiotic susceptibility reporting for these organisms in blood cultures to include narrow spectrum third-generation cephalosporins. We sought to assess the impact of this change on BS antibiotic use and clinical outcomes. We also sought to compare outcomes between BS and narrow spectrum antibiotics in bacteremia caused by these organisms.