2593. Human Monoclonal Antibodies Potently Neutralize Enterovirus D68 in both a Clade-Specific and -Independent Manner

摘要

BackgroundEnterovirus D68 (EV-D68) causes worldwide outbreaks of human respiratory illness with spacio-temporally related outbreaks of acute flaccid myelitis (AFM), a polio-like illness. Numerous seroepidemiology studies show that nearly all humans older than 2 years have EV-D68-neutralizing antibodies in their serum, even in serum collected prior to large outbreaks. However, little else is known about the human antibody response to this virus. We sought to isolate human monoclonal antibodies (mAbs) from B cells in peripheral blood mononuclear cells (PBMCs) of immune subjects, induced by natural infection, to understand human humoral immunity to EV-D68.