739. Prediction of Cefiderocol Pharmacokinetics and Probability of Target Attainment in Pediatric Subjects for Proposing Dose Regimens

摘要

BackgroundCefiderocol is a siderophore cephalosporin discovered by Shionogi & Co., Ltd., which exhibits potent efficacy against Gram-negative carbapenem-resistant bacteria. Pediatric clinical studies are planned. Cefiderocol is mainly renally eliminated. A 2-g infusion of cefiderocol over 3 hours, every 8 hours (q8h) is the recommended dose regimen in adults. In this study, dose regimens for pediatric subjects (birth to <18 years old) are proposed based on predictions of pharmacokinetics (PK) in pediatrics using data from adults to provide adequate exposure.