Alleviation of Acute Lung Injury in Rats with Sepsis by Resveratrol via the Phosphatidylinositol 3-Kinase/Nuclear Factor-Erythroid 2 Related Factor 2/Heme Oxygenase-1 (PI3K/Nrf2/HO-1) Pathway

机译：白藜芦醇通过磷脂酰肌醇3-激酶/核因子-类胡萝卜素2相关因子2 /血红素加氧酶-1（PI3K / Nrf2 / HO-1）途径减轻白藜芦醇对脓毒症大鼠的急性肺损伤

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BackgroundResveratrol (Res) is a type of polyphenol found in many plants, which can protect important organs from the damage induced by sepsis. However, the exact mechanism of its protective effect has not been established. This study investigated the effect of Res on the PI3K/Nrf2/HO-1 signaling pathway in rats with sepsis-induced acute lung injury (ALI).

机译：背景白藜芦醇（Res）是许多植物中发现的一种多酚，可以保护重要器官免受败血症引起的损害。但是，尚未确定其保护作用的确切机制。这项研究调查了Res对败血症诱导的急性肺损伤（ALI）大鼠PI3K / Nrf2 / HO-1信号通路的影响。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Yu Wang; Xiaofeng Wang; Lichun Zhang; Rong Zhang;
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作者单位

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年(卷),期 1923(24),
年度 1923
页码 3604–3611
总页数 8
原文格式 PDF
正文语种
中图分类
关键词
Acute Lung Injury, Sepsis, Signal Transduction;

机译：急性肺损伤;败血症;信号转导;

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专利

1. Diosmetin Ameliorates Cerebral Ischemia/Reperfusion Injury in PC12 Cells Through Nuclear Factor-kB (NF-kB) and Nuclear Factor Erythroid 2-Related Factor/Heme Oxygenase-1 (Nrf2/HO-1) Pathway [J] . Luan Lan, Cao Lanxiu, Zhu Lei, Current topics in nutraceutical research . 2019,第3期

机译：Diosmetin通过核因子-KB（NF-KB）和核因子红外2相关因子/血红素氧酶-1（NRF2 / HO-1）途径（NRF2 / HO-1）途径
2. Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells [J] . Harrison EM, McNally SJ, Devey L, The FEBS journal . 2006,第11期

机译：胰岛素通过磷脂酰肌醇3-激酶/ Akt途径和肾细胞中的Nrf2转录因子诱导血红素加氧酶-1
3. Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells [J] . Harrison EM, McNally SJ, Devey L, The FEBS journal . 2006,第11期

机译：胰岛素通过磷脂酰肌醇3-激酶/ Akt途径和肾细胞中的Nrf2转录因子诱导血红素加氧酶-1
4. Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats [C] . Shuyu Zhang, Jinchang Wu, Chuanjun Song, 2011 Asia-Pacific Conference of tumor biology and medicine . 2011

机译：腺病毒介导的血红素加氧酶-1（HO-1）过表达改善辐射诱发的皮肤损伤
5. Use of Tat-HSP70 fusion protein to attenuate sepsis-induced lung injury in rodents with acute respiratory distress syndrome caused by cecal ligation and double puncture (2CLP) [D] . Lyons, Mary Melanie 2013

机译：使用TAT-HSP70融合蛋白在术中患有急性呼吸窘迫综合征的啮齿动物患者患者患者患者引起的盲肠结扎和双刺穿（2CLP）
6. L-Carnitine Reduces Myocardial Oxidative Stress and Alleviates Myocardial Ischemia-Reperfusion Injury by Activating Nuclear Transcription-Related Factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) Signaling Pathway [O] . Tana Zhao, Shangjun Chen, Bingxin Wang, 2020

机译：左旋肉碱通过激活核转录相关因子2（Nrf2）/血红素加氧酶-1（HO-1）信号通路来减轻心肌氧化应激并减轻心肌缺血再灌注损伤。
7. Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway [O] . Xiuling Shang, Kaiyang Lin, Rongguo Yu, 2019

机译：通过激活磷脂酰肌醇3-激酶（PI3K）/ Akt /哺乳动物靶雷帕霉素（MTOR）途径并抑制核因子-κB（NF-κB）信号通路，通过激活脓毒症（PI3K）/ Akt /哺乳动物靶标来保护心肌胰岛素

Alleviation of Acute Lung Injury in Rats with Sepsis by Resveratrol via the Phosphatidylinositol 3-Kinase/Nuclear Factor-Erythroid 2 Related Factor 2/Heme Oxygenase-1 (PI3K/Nrf2/HO-1) Pathway

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