Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad

摘要

Suppression of STAT3 target-gene expressions by STX-0119 in lung cancer cells. Effect of STX-0119 on Tyr705 phosphorylation of STAT3 in A549 cells. Cells were treated with indicated doses of STX-0119 for 48 h. Subcellular localization of STAT3 in STX-0119-treated A549 cells. Protein expressions of c-Myc, cyclin D1, and survivin in A549 cells after STX-0119 treatment for 48 h